QUANTITATIVE ASPECTS OF THE REACTION BETWEEN INSULIN AND INSULIN-BINDING ANTIBODY

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منابع مشابه

Quantitative Aspects of the Reaction between Insulin

The presence of insulin-binding antibodies in the serums of insulin-treated subjects has been reported previously (1). With I"ll-labeled insulin it has been shown that the antigen-antibody complexes do not precipitate, that the binding of insulin to antibody is a reversible process, and that, at constant antibody concentration, the ratio of bound insulin to free insulin is an inverse function o...

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15 صفحه اول

Studies on nonprecipitating insulin antibody. Radioimmunoassay of insulin binding capacity and its relationship to insulin neutralizing activity and ability to evoke cutaneous anaphylactic reaction.

Skom and Talmage have demonstrated a non-precipitating antibody against insulin in the sera of insulin-treated diabetics. But their method of determining the antibody is not quantitative. In the present study, a titration of the insulin binding activity of anti-insulin was performed more quantitatively using 1311-labeled insulin and antiguinea pig r-globulin rabbit sera under the condition of i...

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ژورنال

عنوان ژورنال: Journal of Clinical Investigation

سال: 1959

ISSN: 0021-9738

DOI: 10.1172/jci103979